diff --git src/bp-core/bp-core-catchuri.php src/bp-core/bp-core-catchuri.php
index 3c6bc5b..5917b84 100644
--- src/bp-core/bp-core-catchuri.php
+++ src/bp-core/bp-core-catchuri.php
@@ -241,8 +241,11 @@ function bp_core_set_uri_globals() {
 
 	// Rejig the offset
 	if ( !empty( $slug ) && ( 1 < count( $slug ) ) ) {
-		array_pop( $slug );
-		$uri_offset = count( $slug );
+		// Only offset if not on a root profile. Fixes issue when Members page is nested.
+		if ( false === $root_profile ) {
+			array_pop( $slug );
+			$uri_offset = count( $slug );
+		}
 	}
 
 	// Global the unfiltered offset to use in bp_core_load_template().
diff --git tests/phpunit/testcases/routing/root-profiles.php tests/phpunit/testcases/routing/root-profiles.php
index fc6403e..e889eef 100644
--- tests/phpunit/testcases/routing/root-profiles.php
+++ tests/phpunit/testcases/routing/root-profiles.php
@@ -42,6 +42,29 @@ class BP_Tests_Routing_Members_Root_Profiles extends BP_UnitTestCase {
 		$this->assertEquals( $this->u->ID, bp_displayed_user_id() );
 	}
 
+	/**
+	 * @ticket BP6475
+	 */
+	public function test_member_permalink_when_members_page_is_nested_under_wp_page() {
+		$p = $this->factory->post->create( array(
+			'post_type' => 'page',
+			'post_name' => 'foo',
+		) );
+
+		$members_page = get_page_by_path( 'members' );
+		wp_update_post( array(
+			'ID' => $members_page->ID,
+			'post_parent' => $p,
+		) );
+
+		$domain = home_url( $this->u->user_nicename );
+		$this->go_to( $domain );
+
+		$this->assertTrue( bp_is_user() );
+		$this->assertTrue( bp_is_my_profile() );
+		$this->assertEquals( $this->u->ID, bp_displayed_user_id() );
+	}
+
 	public function test_member_activity_page() {
 		$url = home_url( $this->u->user_nicename ) . '/' . bp_get_activity_slug();
 		$this->go_to( $url );